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Complex genomic landscape of inversion polymorphism in Europe's most destructive forest pest

dc.contributor.authorMykhailenko, Anastasiia
dc.contributor.authorZieliński, Piotr
dc.contributor.authorBednarz, Aleksandra
dc.contributor.authorSchlyter, Fredrik
dc.contributor.authorAndersson, Martin N
dc.contributor.authorAntunes, Bernardo
dc.contributor.authorBorowski, Zbigniew
dc.contributor.authorKrokene, Paal
dc.contributor.authorMelin, Markus
dc.contributor.authorMorales-García, Julia
dc.contributor.authorMüller, Jörg
dc.contributor.authorNowak, Zuzanna
dc.contributor.authorSchebeck, Martin
dc.contributor.authorStauffer, Christian
dc.contributor.authorViiri, Heli
dc.contributor.authorZaborowska, Julia
dc.contributor.authorBabik, Wiesław
dc.contributor.authorNadachowska-Brzyska, Krystyna
dc.contributor.departmentid4100110710
dc.contributor.orcidhttps://orcid.org/0000-0001-7290-9203
dc.contributor.organizationLuonnonvarakeskus
dc.date.accessioned2024-12-31T09:12:15Z
dc.date.accessioned2025-05-28T11:36:09Z
dc.date.available2024-12-31T09:12:15Z
dc.date.issued2024
dc.description.abstractIn many species, polymorphic genomic inversions underlie complex phenotypic polymorphisms and facilitate local adaptation in the face of gene flow. Multiple polymorphic inversions can co-occur in a genome, but the prevalence, evolutionary significance, and limits to complexity of genomic inversion landscapes remain poorly understood. Here, we examine genome-wide genetic variation in one of Europe's most destructive forest pests, the spruce bark beetle Ips typographus, scan for polymorphic inversions, and test whether inversions are associated with key traits in this species. We analyzed 240 individuals from 18 populations across the species' European range and, using a whole-genome resequencing approach, identified 27 polymorphic inversions covering ∼28% of the genome. The inversions vary in size and in levels of intra-inversion recombination, are highly polymorphic across the species range, and often overlap, forming a complex genomic architecture. We found no support for mechanisms such as directional selection, overdominance, and associative overdominance that are often invoked to explain the presence of large inversion polymorphisms in the genome. This suggests that inversions are either neutral or maintained by the combined action of multiple evolutionary forces. We also found that inversions are enriched in odorant receptor genes encoding elements of recognition pathways for host plants, mates, and symbiotic fungi. Our results indicate that the genome of this major forest pest of growing social, political, and economic importance harbors one of the most complex inversion landscapes described to date and raise questions about the limits of intraspecific genomic architecture complexity.
dc.description.vuosik2024
dc.format.bitstreamtrue
dc.format.pagerange12 p.
dc.identifier.citationHow to cite: Anastasiia Mykhailenko, Piotr Zieliński, Aleksandra Bednarz, Fredrik Schlyter, Martin N Andersson, Bernardo Antunes, Zbigniew Borowski, Paal Krokene, Markus Melin, Julia Morales-García, Jörg Müller, Zuzanna Nowak, Martin Schebeck, Christian Stauffer, Heli Viiri, Julia Zaborowska, Wiesław Babik, Krystyna Nadachowska-Brzyska, Complex Genomic Landscape of Inversion Polymorphism in Europe's Most Destructive Forest Pest, Genome Biology and Evolution, Volume 16, Issue 12, December 2024, evae263, https://doi.org/10.1093/gbe/evae263
dc.identifier.olddbid498410
dc.identifier.oldhandle10024/555838
dc.identifier.urihttps://jukuri.luke.fi/handle/11111/22145
dc.identifier.urlhttps://doi.org/10.1093/gbe/evae263
dc.identifier.urnURN:NBN:fi-fe20241231106853
dc.language.isoen
dc.okm.avoinsaatavuuskytkin1 = Avoimesti saatavilla
dc.okm.corporatecopublicationei
dc.okm.discipline4112
dc.okm.internationalcopublicationon
dc.okm.julkaisukanavaoa1 = Kokonaan avoimessa julkaisukanavassa ilmestynyt julkaisu
dc.okm.selfarchivedon
dc.publisherOxford University Press
dc.relation.articlenumberevae263
dc.relation.doi10.1093/gbe/evae263
dc.relation.ispartofseriesGenome biology and evolution
dc.relation.issn1759-6653
dc.relation.numberinseries12
dc.relation.volume16
dc.rightsCC BY 4.0
dc.source.identifierhttps://jukuri.luke.fi/handle/10024/555838
dc.subjectpolymorphic inversions
dc.subjectgenome complexity
dc.subjectspruce bark beetle
dc.subjectIps typographus
dc.subjectforest pest
dc.tehOHFO-Puskuri-4
dc.titleComplex genomic landscape of inversion polymorphism in Europe's most destructive forest pest
dc.typepublication
dc.type.okmfi=A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä|sv=A1 Originalartikel i en vetenskaplig tidskrift|en=A1 Journal article (refereed), original research|
dc.type.versionfi=Publisher's version|sv=Publisher's version|en=Publisher's version|

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