Geographical Distribution and Genetic Diversity of Bank Vole Hepaciviruses in Europe
Schneider, Julia; Hoffmann, Bernd; Fevola, Cristina; Schmidt, Marie Luisa; Imholt, Christian; Fischer, Stefan; Ecke, Frauke; Hörnfeldt, Birger; Magnusson, Magnus; Olsson, Gert E.; Rizzoli, Annapaola; Tagliapietra, Valentina; Chiari, Mario; Reusken, Chantal; Bužan, Elena; Kazimirova, Maria; Stanko, Michal; White, Thomas A.; Reil, Daniela; Obiegala, Anna; Meredith, Anna; Drexler, Jan Felix; Essbauer, Sandra; Henttonen, Heikki; Jacob, Jens; Hauffe, Heidi C.; Beer, Martin; Heckel, Gerald; Ulrich, Rainer G. (2021)
Schneider, Julia
Hoffmann, Bernd
Fevola, Cristina
Schmidt, Marie Luisa
Imholt, Christian
Fischer, Stefan
Ecke, Frauke
Hörnfeldt, Birger
Magnusson, Magnus
Olsson, Gert E.
Rizzoli, Annapaola
Tagliapietra, Valentina
Chiari, Mario
Reusken, Chantal
Bužan, Elena
Kazimirova, Maria
Stanko, Michal
White, Thomas A.
Reil, Daniela
Obiegala, Anna
Meredith, Anna
Drexler, Jan Felix
Essbauer, Sandra
Henttonen, Heikki
Jacob, Jens
Hauffe, Heidi C.
Beer, Martin
Heckel, Gerald
Ulrich, Rainer G.
Julkaisusarja
Viruses
Volyymi
13
Numero
7
Sivut
14 p.
MDPI
2021
Julkaisun pysyvä osoite on
http://urn.fi/URN:NBN:fi-fe2021121761379
http://urn.fi/URN:NBN:fi-fe2021121761379
Tiivistelmä
The development of new diagnostic methods resulted in the discovery of novel hepaciviruses in wild populations of the bank vole (Myodes glareolus, syn. Clethrionomys glareolus). The naturally infected voles demonstrate signs of hepatitis similar to those induced by hepatitis C virus (HCV) in humans. The aim of the present research was to investigate the geographical distribution of bank vole-associated hepaciviruses (BvHVs) and their genetic diversity in Europe. Real-time reverse transcription polymerase chain reaction (RT-qPCR) screening revealed BvHV RNA in 442 out of 1838 (24.0%) bank voles from nine European countries and in one of seven northern red-backed voles (Myodes rutilus, syn. Clethrionomys rutilus). BvHV RNA was not found in any other small mammal species (n = 23) tested here. Phylogenetic and isolation-by-distance analyses confirmed the occurrence of both BvHV species (Hepacivirus F and Hepacivirus J) and their sympatric occurrence at several trapping sites in two countries. The broad geographical distribution of BvHVs across Europe was associated with their presence in bank voles of different evolutionary lineages. The extensive geographical distribution and high levels of genetic diversity of BvHVs, as well as the high population fluctuations of bank voles and occasional commensalism in some parts of Europe warrant future studies on the zoonotic potential of BvHVs.
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